Clinical management of polycystic kidney disease
نویسندگان
چکیده
منابع مشابه
Clinical management of polycystic kidney disease.
ADPKD is caused by mutations in two genes:1,2 PKD1 on chromosome 16p13.3, and PKD2, on chromosome 4q21-23. The proteins encoded by PKD1 and PKD2 are polycystin-1 and polycystin-2 (Fig 1).3 Polycystin-1 is probably involved in protein-protein or proteincarbohydrate interactions. Polycystin-2 is a nonselective cation channel that can conduct calcium ions. Mutations in either PKD1 or PKD2 prod...
متن کاملAutosomal dominant polycystic kidney disease: recent advances in clinical management
The first clinical descriptions of autosomal dominant polycystic kidney disease (ADPKD) go back at least 500 years to the late 16 (th) century. Advances in understanding disease presentation and pathophysiology have mirrored the progress of clinical medicine in anatomy, pathology, physiology, cell biology, and genetics. The identification of PKD1 and PKD2, the major genes mutated in ADPKD, has ...
متن کاملOptimising the management of polycystic kidney disease.
Polycystic kidney disease (PKD) is the most common inherited renal disorder that results in chronic kidney disease. PKD has an autosomal dominant pattern of inheritance. The prevalence is between 1:500 and 1:1,000. Up to 10% of adults with end-stage renal disease (ESRD) have a genetic disorder such as PKD. A family history of PKD may be absent in up to 25% of affected individuals. The most comm...
متن کاملManagement of autosomal dominant polycystic kidney disease
A utosomal dominant polycystic kidney disease (ADPKD) is a genetic condition characterised by the formation of multiple fluid-filled renal cysts and kidney enlargement. Potential complications of ADPKD include adult-onset end-stage kidney disease, early-onset hypertension and nephrolithiasis. ADPKD is also associated with systemic conditions including intracranial cerebral aneurysm and polycyst...
متن کاملKHA-CARI Autosomal Dominant Polycystic Kidney Disease Guideline: Management of Polycystic Liver Disease.
a. We recommend screening for polycystic liver disease in all patients diagnosed with autosomal dominant polycystic kidney disease using abdominal ultrasound (1C). b. We recommend that all female patients with autosomal dominant polycystic kidney disease and liver cysts undergo counseling regarding the risks of pregnancy and exogenous estrogen exposure in worsening liver cyst growth (1C). c. We...
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ژورنال
عنوان ژورنال: Clinical Medicine
سال: 2003
ISSN: 1470-2118,1473-4893
DOI: 10.7861/clinmedicine.3-6-509